A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
- 19 July 1990
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 346 (6281) , 240-244
- https://doi.org/10.1038/346240a0
Abstract
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.Keywords
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