PHARMACOLOGY OF PROCAINE IN HORSE - EVIDENCE AGAINST EXISTENCE OF A PROCAINE PENICILLIN COMPLEX

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (4) , 437-442
Abstract
When procaine penicillin was given i.m. to horses, about 90% of the procaine in blood drawn from these horses dissociated at the same rate as authentic procaine or procaine penicillin added to equine blood in vitro. In vitro, procaine and procaine penicillin partitioned similarly from aqueous medium at physiologic pH into several organic solvents and were split at the same rate by blood or plasma esterases. Experiments on the time course of the partitioning of procaine from procaine penicillin into benzene showed no evidence for the existence of a procaine.cntdot.penicillin complex within seconds after procaine penicillin was added to aqueous medium. TLC in 2 dimensions yielded no evidence for the existence of this postulated complex. No evidence in support of the procaine.cntdot.penicillin hypothesis and its physical, pharmacologic and forensic implications was shown.