Ultramicroanalysis of Peptide Profiles in Biological Samples Using MALDI Mass Spectrometry
- 11 September 1998
- journal article
- review article
- Published by S. Karger AG in Nephron Experimental Nephrology
- Vol. 6 (5) , 421-428
- https://doi.org/10.1159/000020551
Abstract
In the past few years, matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has emerged as a powerful tool for the direct analysis of peptide profiles contained in single neuroendocrine cells, tissue biopsies, as well as in releasates (after a simple sample clean-up). These studies were performed in both invertebrate (the pond snail) and vertebrate (xenopus and rat) species. The present article provides an overview of these data with a special emphasis on the sample handling required for each application.Keywords
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