THE EXCRETION OF IODINE IN EXPERIMENTAL HYPERTHYROIDISM

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Abstract
About 50% of the I from whole thyroids or thyroglobulin fed to 15 dogs (10 normal, 5 thyroidectomized) was eliminated through the urine, while in only 3 of 7 biliary fistula dogs did a trace of I appear in the bile after thyroid feeding. After intravenous thyroxine in 7 dogs a greater proportion of the injected I appeared in the bile than in the urine. After an intravenous injection of thyroxine, about 1/2 of the I is excreted in the bile and urine before a rise in metabolism occurs. Since very little I appears in the bile after feeding large doses of desiccated thyroid, it is concluded that free thyroxine is not liberated.

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