Cell Differentiation and Its Control in the Vertebrate Epidermis

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Abstract
SYNOPSIS Patterns of cell differentiation in the general body epidermis of veitebrates vary from class to class and within certain classes In fish,a multiplicity of non keratinued differentiated cells are found overthe body Then presence is readily explained on the basis each arising from a distinctive precursor in the germinal layer In amphibians and mammals all cells foim alpha keratin In birds and some reptiles beta keratin is found over some parts ofthe body and alpha keratin is found elsewhere These regional differences are probably based on certain spicific dermal influences In the epidermis of squamate reptiles, the fate of cells that have left thegerminal layei alternates between synthesis of ben oi alpha keratin in a manner unique among the vertebrates Theie is evidence to suggest that feedback loops within the epidermis coupled to specific patterns of cell behavior in the geiminal layer aie important in legulating the lemaikable switch in piotein synthetic pathways

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