An Analysis of Water Movement between Myocardial Tissue and Capillary Blood during Reactive Hyperemia

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Abstract
The colloid osmotic pressure (COP) of blood from the great cardiac vein was continuously measured by a membrane colloid osmometer during reactive hyperemia after temporary occlusion of the anterior descending branch of the left coronary artery in anesthetized open-chest dogs. The COP increased sharply after releasing the occlusion then decreased below the preocclusion level before gradually returning to it. Apparently a measurable amount of water moved from the capillary blood into the myocardial tissues and then flowed back slowly into the capillary blood. To analyze the factors affecting this water movement a method is proposed in which the Starling mechanism is combined with the interstitial volume elasticity and a steady-state solution of a Navier-Stokes equation. Capillary perfusion pressure was measured by a catheter wedged into a branch of the great cardiac vein. During coronary artery occlusion the filtration constant increased while the volume elasticity of the myocardial interstitial spaces decreased. The filtration constant and volume elasticity of the interstitial space under normal conditions were estimated to be 2.4 .times. 10-11 cm/(s .cntdot. dyn .cntdot. cm-2) and 1.1 .times. 107 dyn .cntdot. cm-2, respectively.

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