X‐Arrestin: a new retinal arrestin mapping to the X chromosome
- 15 November 1993
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 334 (2) , 203-209
- https://doi.org/10.1016/0014-5793(93)81712-9
Abstract
We have been using a differential cDNA cloning approach to isolate human retina-specific and retina-enriched genes [1]. A 1,314 bp cDNA was isolated by this approach, representing a highly retina-specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine β-arrestin, and bovine and human retinal arrestin (S-antigen), respectively. Chromosomal mapping localized this new arrestin genc to the proximal long arm of the X chromosome, hence it was named X-arrestin. In situ hybridization demonstrated its expression in the inner and outer segments and the inner plexiform regions of the retina.Keywords
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