Chemogenomic approaches to drug discovery: similar receptors bind similar ligands
- 1 September 2007
- journal article
- editorial
- Published by Wiley in British Journal of Pharmacology
- Vol. 152 (1) , 5-7
- https://doi.org/10.1038/sj.bjp.0707308
Abstract
Within recent years, a paradigm shift from traditional receptor-specific studies to a cross-receptor view has taken place within pharmaceutical research to increase the efficiency of modern drug discovery. Receptors are no longer viewed as single entities but grouped into sets of related proteins or receptor families that are explored in a systematic manner. This interdisciplinary approach attempting to derive predictive links between the chemical structures of bioactive molecules and the receptors with which these molecules interact is referred to as chemogenomics. Insights from chemogenomics are used for the rational compilation of screening sets and for the rational design and synthesis of directed chemical libraries to accelerate drug discovery.Keywords
This publication has 10 references indexed in Scilit:
- Chemogenomic approaches to rational drug designBritish Journal of Pharmacology, 2007
- Chemogenomics Approaches to Ligand DesignPublished by Wiley ,2006
- A physicogenetic method to assign ligand-binding relationships between 7TM receptorsBioorganic & Medicinal Chemistry Letters, 2005
- Virtual Screen for Ligands of Orphan G Protein-Coupled ReceptorsJournal of Chemical Information and Modeling, 2005
- Chemogenomics in Drug DiscoveryPublished by Wiley ,2004
- Selective Optimization of Side Activities: Another Way for Drug DiscoveryJournal of Medicinal Chemistry, 2004
- Property-Based Design of GPCR-Targeted LibraryJournal of Chemical Information and Computer Sciences, 2002
- Chemogenomic approaches to drug discoveryCurrent Opinion in Chemical Biology, 2001
- The Nobel ChroniclesThe Lancet, 2000