Current Studies on a Working Model of CaM Kinase II in Hippocampal Long-Term Potentiation and Memory
Open Access
- 1 January 1999
- journal article
- review article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 79 (1) , 7-15
- https://doi.org/10.1254/jjp.79.7
Abstract
There have been recent advances in understanding the molecular basis of the long-term potentiation (LTP) of synaptic transmission in the hippocampus. This review documents current views on mechanisms underlying LTP induction, from activation of the NMDA receptor to stimulation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). We will focus in particular on recent findings of how CaM kinase II encodes the frequency of synaptic usage and serves as a molecular memory switch at the synapse. Furthermore, a role for CaM kinase II in spatial learning and memory is demonstrated by recent studies using transgenic mice.Keywords
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