METABOLISM OF STYRENE OXIDE IN ISOLATED PERFUSED RAT-LIVER - IDENTIFICATION AND QUANTITATION OF MAJOR METABOLITES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 5  (4) , 363-367
Abstract
[Styrene is an environmental pollutant.] Isolated perfused rat livers rapidly metabolized 14C-styrene oxide. A large proportion of the administered radioactivity was excreted in the bile as a single compound that was identified as S-(1-phenyl-2-hydroxyethyl)glutathione by comparison with an authentic synthetic standard. The circulating perfusate was found to contain approximately equal amounts of styrene glycol, mandelic acid, and the glutathione derivative.

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