High Levels of Recombinant CYP3A4 Expression in Chinese Hamster Ovary Cells Are Modulated by Coexpressed Human P450 Reductase and Hemin Supplementation
- 1 December 1997
- journal article
- Published by Elsevier in Archives of Biochemistry and Biophysics
- Vol. 348 (2) , 403-410
- https://doi.org/10.1006/abbi.1997.0405
Abstract
No abstract availableKeywords
Funding Information
- Biotechnology and Biological Sciences Research Council
- Department of Trade and Industry
This publication has 24 references indexed in Scilit:
- Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coliPublished by Wiley ,1999
- Recombinant DNA technology as an investigative tool in drug metabolism researchAdvanced Drug Delivery Reviews, 1996
- Roles of Divalent Metal Ions in Oxidations Catalyzed by Recombinant Cytochrome P450 3A4 and Replacement of NADPH-Cytochrome P450 Reductase with Other Flavoproteins, Ferredoxin, and Oxygen SurrogatesBiochemistry, 1995
- Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1Pharmacogenetics, 1995
- Noninvasive tests of CYP3A enzymesPharmacogenetics, 1994
- The Human Hepatic Cytochromes P450 Involved in Drug MetabolismCritical Reviews in Toxicology, 1992
- The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3Carcinogenesis: Integrative Cancer Research, 1991
- Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesCell, 1986
- Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductaseBiochemistry, 1978
- The mechanism of liver microsomal lipid peroxidationBiochimica et Biophysica Acta (BBA) - General Subjects, 1975