Parameters of linear-quadratic radiation dose-effect relationships: dependence on LET and mechanisms of reproductive cell death
Open Access
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 71 (6) , 649-655
- https://doi.org/10.1080/095530097143653
Abstract
An analysis of mammalian cell radiation-dose survival curves, based on the linear-quadratic formalism, is shown to yield insights in the various components of damage that contribute to cell reproductive death. RBE -LET relationships of single-track lethal damage, sublethal damage, potentially lethal damage and DNA double-strand breaks are compared. Singletrack lethal damage is derived to be composed of two components: (1) damage that remains unrepaired in an interval between irradiation and assay for proliferative capacity, with a very strong dependence on LET, and (2) potentially lethal damage that is only weakly dependent on LET, similar to sublethal damage and DNA double-strand breaks. The results of this analysis lead to new interpretations of published experimental results and to suggestions for applications in radiotherapy.Keywords
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