Synthesis and xanthine oxidase inhibitory analysis of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione (3,7-dideazaxanthine) and two of its derivatives
- 1 September 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (9) , 990-993
- https://doi.org/10.1021/jm00207a028
Abstract
The synthesis of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione(3,7-dideazaxanthine) (1), 5-methyl-1H-pyrrolo-[3,2-c]pyridine-4,6(5H,7H)-dione(1-methyl-3,7-dideazaxanthine) (2) and 1,7-dihydropyrano[4,3-b]pyrrole-4,6-dione(1-oxa-1,3,7-trideazaxanthine) (3) was accomplished from 3-alkoxycarbonylpyrrole-2-acetates and from 3-carboxypyrrole-2-acetic acid. Compounds 1 and 2 were weak inhibitors of the noncompetitive type for xanthine oxidase while 3 showed no inhibitory properties toward this enzyme.This publication has 4 references indexed in Scilit:
- 1H‐pyrrolo[3,2‐c]pyridin‐4,6(5H,7H)dione(3,7‐dideazaxanthine)Journal of Heterocyclic Chemistry, 1977
- Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursorsJournal of the American Chemical Society, 1976
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- The Determination of Enzyme Dissociation ConstantsJournal of the American Chemical Society, 1934