Evaluation and Differential Diagnosis of the Hypotonic Infant

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Abstract
Floppiness or hypotonia in an infant is a common clinical problem and may be associated with a wide range of apparently unrelated disorders. It may be the presenting feature of a neuromuscular disorder; it may occur in the newborn period as a result of a perinatal insult to the central nervous system or may manifest later in infants with mental retardation or cerebral palsy; it may be a manifestation of a connective tissue disorder; it may be associated with various metabolic disorders in infancy; it may be an incidental and nonspecific feature of an acutely ill child and it is completely physiologic in the premature infant.

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