Alkaline Phosphatase Activity of Human Serum in Cancer.

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Abstract
No specificity or differentiation of serum alkaline phosphatase using ATP, yeast adenylic acid or beta-glycerol-phosphate as substrates could be demonstrated. The sera of normal and non-cancerous individuals have the same magnitude of dephosphorylation. In patients having a malignant tumor, phosphorus release of the serum was generally higher than the normal and non-cancerous group. The highest values were found in patients with tumors of the liver, pancreas and genito-urinary system. The sera of patients from whom a malignant tumor had been previously removed showed a phosphorus release which was identical with the normal and non-cancerous group. Yeast adenylic acid substrate gave the most consistent results.

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