Gluconeogenesis in the Guinea Pig. Effect of Glucagon on Gluconeogenesis from Lactate by Isolated Perfused Guinea-Pig Liver

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Abstract
Gluconeogenesis was stimulated by glucagon in fed but not fasted isolated perfused guinea pig livers. Both the amount and the rate of incorporation of radioactivity into glucose from L-U-14C-lactate were increased in fed livers by the addition of glucagon to the perfusate. The glucagon-stimulated increase in gluconeogenesis was accompanied by an increase in O2 consumption, an increase in the amount of lactate C converted to glucose and a decrease in the amount of lactate C converted to CO2. Glucagon appears to affect gluconeogenesis from lactate in fed livers by redirecting the fate of substrate from other products toward glucose.

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