Variation in Thyroid Function with the Variation in Tracer Dose of131I in the Rat: Selection of Optimum Tracer Dose

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Abstract
Results of the present experiment show that the values of the conversion ratio both at 24th hour and 48th hour after injection vary widely according to the quantity of 131I administered implying that these tracer doses of radioiodine interfere with the normal function of the thyroid gland. At higher doses from 100 [mu]c to 10 [mu]c per rat of 70 g body-weight the conversion ratio is found to be lower than normal. At the lower range from 0.05 [mu]c to 0.01 [mu]c per rat the conversion ratio is unchanged. It is interesting to note that a dose of about 0.5 [mu]c per rat caused a significant increase in the conversion ratio, suggesting that this dose of 131I stimulates the thyroid gland.