Role of monoamines in behavior of reserpinized rats given tranylcypromine stereoisomers

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Abstract
Summary The effects of tranylcypromine Stereoisomers [(+)-TCP and (−)-TCP] on behavior were studied in reserpinized rats. Rats given reserpine showed a behavioral syndrome characterized by hypoactivity. Administration of (+)-TCP to reserpinized rats led to a dose-dependent increase in their locomotor activity. At a dose of 15 mg/kg, (+)-TCP produced activation, stereotypy and hyperstimulation in reserpinized rats. In contrast, (−)-TCP failed to influence the behavior of reserpinized rats reliably. Pharmacological studies using agonists and antagonists of monoaminergic functions showed the actions of (+)-TCP to depend on presynaptic serotonergic and catecholaminergic functions. The results provide another example of stereoselective effects of tranylcypromine stereoisomers on behavior mediated mainly by monoaminergic neurotransmission.