Cryoglobulins in Coronary-Artery Disease

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Abstract
COMPREHENSIVE essays on cold-precipitable substances in serum have been provided by Barr, Reader and Wheeler,1 and by Lerner and Watson,2 who suggested the descriptive term "cryoglobulin." Such substances probably include several groups of proteins, and perhaps other compounds. When present in large amounts, cryoglobulin of itself produces a well defined clinical syndrome similar to Raynaud's disease. Although Rörvik3 stated that even small amounts of cryoglobulin must be considered pathologic, only one clinical study of a disease with small amounts of cold-precipitable substance has been made. That report, by Dreyfuss and Librach,4 suggested that the high incidence of cold-precipitable substance in . . .