EFFECT OF DIAZEPAM ON PANCURONIUM-INDUCED NEUROMUSCULAR BLOCKADE MAINTAINED BY A FEEDBACK SYSTEM

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Abstract
The possibility of an interaction between diazepam and pancuronium bromide was investigated in six patients undergoing general anaesthesia maintained with fentanyl, droperidol and nitrous oxide. Neuromuscular blockade was controlled using a feedback mechanism which automatically adjusted the rate of injection of pancuronium to maintain between 71.4 and 72.9% blockade. Diazepam 0.14mg kg–1 i.v. produced blood concentrations within the therapeutic range, but did not produce consistent changes in the level of blockade, pancurornum concentration in the blood or pancuroniurn consumnrion measured over 20 nun.