Quantitative relationship between volume of tumour cell units and their intravascular survival
Open Access
- 1 February 1978
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 37 (2) , 248-253
- https://doi.org/10.1038/bjc.1978.33
Abstract
The derivation of the median volume (MV) and the geometric standard deviation (SDg) for a suspension of tumour cells quantifies the size and distribution of tumour cell aggregates in the suspension. Data collected in a group of 14 experiments shwoed a significant correlation of 0.80 (P less than 0.001) between the number of lung tumours formed by a suspension of B16 melanoma cells injected i.v. into C57BL/6J mice and the product of the MV and SDg of each cell suspension. These data define a size parameter of tumour cell suspensions that correlates with the intravascular survival properties of tumour cells.Keywords
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