SIGNIFICANCE OF NEUTRALIZING ANTIBODY IN EXPERIMENTAL EQUINE ENCEPHALOMYELITIS
- 20 June 1942
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 119 (8) , 618-620
- https://doi.org/10.1001/jama.1942.02830250014005
Abstract
Our purpose in this report is to direct attention to recent experimental studies which may be applicable to plans for vaccination of man against infection with equine encephalomyelitis virus. That there may be need for such vaccination in the face of an epidemic is indicated by recent events: 1. An apparent increase in the incidence of the human disease has occurred; in 1941 more than 3,000 clinically recognized cases due to the western virus were reported in the Northwestern states and in adjacent provinces of Canada.12. Western virus was isolated from mosquitoes,2from horses and from 1 prairie chicken3in endemic areas. 3. Since antibody to the same virus was found in a large variety of birds and mammals, they are suspected of being natural reservoirs of virus.4Thus the difficulty of eliminating all actual and potential sources of infection is indeed great. The apparentlyKeywords
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