The sheep(Ovis aries)as an experimental model for African trypanosomiasis
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 82 (2) , 141-148
- https://doi.org/10.1080/00034983.1988.11812221
Abstract
Sheep were used as an experimental model to study trypanosomiasis. Twelve animals were infected with Trypanosoma brucei brucei, and the clinical evolution of the disease in the sheep corresponded closely to that described in human patients. The main clinical signs of the experimental infection were hyperthermia, anaemia, loss of weight and behavioural disturbances. Death occurred in all cases after a mean time of 75 days. Trypanosomes were detected in blood films nine to 15 days after inoculation, and the parasitaemia was usually mild and irregular. Changes in the cerebrospinal fluid—increase in leucocyte counts and the presence of trypanosomes—appeared after about 45 days. This model would provide a valuable way of testing the effectiveness of new therapeutic drugs.This publication has 12 references indexed in Scilit:
- The sheep (Ovis aries) as an experimental model for African trypanosomiasisPathogens and Global Health, 1988
- Immunopathological aspects of trypanosomal meningoencephalitis in vervet monkeys after relapse following BerenilR treatmentTransactions of the Royal Society of Tropical Medicine and Hygiene, 1985
- The pathogenesis of sleeping sicknessPublished by Oxford University Press (OUP) ,1980
- Immunopathological and chemotherapeutic studies in experimental trypanosomiasis with special reference to the heart and brainTransactions of the Royal Society of Tropical Medicine and Hygiene, 1980
- Pathogenesis of Trypanosoma brucei infection in sheepJournal of Comparative Pathology, 1975
- Pathogenesis of Trypanosoma brucel infection in sheepJournal of Comparative Pathology, 1975
- Pathogenesis of Trypanosoma brucei infection in sheepJournal of Comparative Pathology, 1975
- Ocular lesions in sheep infected with Trypanosoma bruceiJournal of Comparative Pathology, 1974
- Pathology of the Disease in Sheep Produced Experimentally by Trypanosoma bruceiVeterinary Pathology, 1972
- Isolation of salivarian trypanosomes from man and other mammals using DEAE-celluloseExperimental Parasitology, 1970