Differential Cerebral Metabolic Changes With Paroxetine Treatment of Obsessive-Compulsive Disorder vs Major Depression

Open Access
Publisher Website
Google Scholar
Abstract
SEROTONIN reuptake inhibitors (SRIs) are effective treatments for several psychiatric disorders, including major depressive disorder (MDD) and obsessive-compulsive disorder (OCD). However, it is not known whether improvements in different clinical syndromes are mediated by the same effects of SRIs on brain function. This study was intended to determine whether the functional neuroanatomical effects of SRI treatment in OCD and MDD depend on the underlying pathophysiology of the clinical syndrome, the degree of symptomatic improvement, or a combination of both factors.