Incisor Abnormality of Senescence Accelerated Mouse (SAM)1

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Abstract
Incisor abnormalities such as loss of enamel color, hypoplasia of enamel, shortening and lengthening, irregular shape of edge, and fracture were often observed in SAM‐P/2/Iw (senescence accelerated mouse‐prone) more than 12 months old. On the other hand, for SAM‐R/1/lw (control) mice more than 20 months old, there were only a few instances of loss of enamel color. The incidence of incisor abnormality was significantly different between P/2/Iw and R/I/Iw. The onset of abnormality was also earlier in P/2/Iw. Histologically, dens in dente and odontoma‐like structures were occasionally found in the incisors of P/2/Iw. These findings add further supporting evidence that SAM‐P/2/Iw is truly senescence accelerated.