Studies of the nerve growth factor in submandibular glands of female mice treated with testosterone

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Abstract
The effect of testosterone propionate administration on the quantity and localization of a nerve growth protein was studied in the submandibular glands of adult female Swiss mice. Testosterone treatment for 14 to 24 days resulted in an increase in the quantity of a nerve growth‐promoting protein approaching those levels found in normal untreated adult male Swiss mice. The nerve growth‐promoting protein was localized by immunofluorescent techniques in the cytoplasm surrounding the zymogenic granules of the serous tubular portions of the submandibular glands in both control and treated animals. The role played by the submandibular gland in the synthesis or storage of this factor is discussed.