Aggregations of 35-Nanometer Particles Associated with Neuronal Cytopathic Changes in Natural Scrapie

29 January 1971

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 171 (3969) , 389-390
https://doi.org/10.1126/science.171.3969.389

Abstract

Neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. Membrane-bound accumulations of the 35-nm particles are fotnd in the cytoplasmic processes that project inside the vacuoles of the neuronal perikaryon. Such particles are present only in a small number of vacuolated neurons.

Keywords

This publication has 4 references indexed in Scilit:

Scrapie in Mice: Ultrastructural Observations in the Cerebral Cortex
Experimental Biology and Medicine, 1968
Nature of the Scrapie Agent
Nature, 1967
The exceptionally small size of the scrapie agent
Biochemical and Biophysical Research Communications, 1966
DEGENERATION OF THE CEREBELLAR AND HYPOTHALAMO NEUROHYPOPHYSIAL SYSTEMS IN SHEEP WITH SCRAPIE; AND ITS RELATIONSHIP TO HUMAN SYSTEM DEGENERATIONS
Brain, 1964