Ultrasonicarly induced nuclear aberrations in anin vitromulticellular tumour system

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Abstract
Chinese hamster V-79 cells, attached to an acoustically transparent membrane, and EMT6/Ro mouse mammary sarcoma cells as small multicellular spheroids or in suspension, were exposed to therapeutic intensities of 1 MHz ultrasound (0-10 W/cm2) and examined for the production of atypical nuclear or chromosomal aberrations. In the monolayer configuration no abnormalities occurred. In multicell spheroids or suspension cells 3 classes of abnormalities were found: pyknotic/irregular nuclei; lysed nuclei with extruding nucleoplasm; and agglomerations which have an irregular shape and fused morphology similar to that which was reported for plant tissues.

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