Brain Atrophy Is Related to Lacunar Lesions and Tissue Microstructural Changes in CADASIL
- 1 June 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 38 (6) , 1786-1790
- https://doi.org/10.1161/strokeaha.106.478263
Abstract
Background and Purpose—Cerebral atrophy has been recently recognized as a key marker of disease progression in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The contribution of subcortical cerebral lesions in this process remains undetermined. The aim of this study was to investigate the relationships between cerebral volume and different types of subcortical MRI lesions in CADASIL.Methods—Demographic, clinical, and laboratory data from 147 patients with CADASIL recruited from a prospective cohort study were analyzed. Validated methods were used to determine the ratio of brain volume to intracranial cavity volume (brain parenchymal fraction [BPF]), volume of white matter hyperintensities, volume of lacunar lesions, number of cerebral microhemorrhages, and mean apparent diffusion coefficient. Associations between BPF, clinical scales, and the different subcortical MRI markers were tested.Results—BPF obtained in 129 patients was significantly associated with the Mattis dementia rating scale (PP=0.002), and modified Rankin scale (PPP=0.004), and age (PConclusions—In association with age, mean apparent diffusion coefficient and volume of lacunar lesions are strong and independent MRI predictors of BPF, a key marker of cognitive and motor disability in CADASIL. These results suggest brain atrophy is related to remote and/or diffuse consequences of both lacunar lesions and widespread microstructural alterations within the brain outside lacunar lesions.Keywords
This publication has 23 references indexed in Scilit:
- Cortical Neuronal Apoptosis in CADASILStroke, 2006
- Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort studyBrain, 2006
- Diffusion Magnetic Resonance Histograms as a Surrogate Marker and Predictor of Disease Progression in CADASILStroke, 2005
- Shape and Volume of Lacunar InfarctsStroke, 2005
- Gray matter reduction is correlated with white matter hyperintensity volume: A voxel-based morphometric study in a large epidemiological sampleNeuroImage, 2005
- White matter lesion progression, brain atrophy, and cognitive decline: The Austrian stroke prevention studyAnnals of Neurology, 2005
- Silent Brain Infarcts and the Risk of Dementia and Cognitive DeclineNew England Journal of Medicine, 2003
- Monitoring Disease Progression in CADASIL With Diffusion Magnetic Resonance ImagingStroke, 2002
- Robust brain segmentation using histogram scale-space analysis and mathematical morphologyPublished by Springer Nature ,1998
- Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementiaNature, 1996