Primate Nutrition II. Riboflavin Deficiency in the Cebus Monkey and Its Diagnosis

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Abstract
Riboflavin deficiency has been studied in the Cebus monkey. Measurement of the plasma riboflavin and its derivatives has been found the most sensitive and specific indicator of deficiency. The deficiency is not associated with pronounced anemia unless growth is stimulated with riboflavin, after which an anemia develops as rapid growth ensues. The maintenance of a normal or nearly normal cell pattern during severe deficiency suggests the possibility of an anoxic stimulus to blood formation. Neither fatty livers nor the collapse syndrome were seen. A significant diminution in liver cholesterol is related to the stressful influence of the deficiency. The endocrine tissues studied, notably the gonads and adrenals, are profoundly influenced by riboflavin deficiency.

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