Mechanisms Of Carcinogenesis of Polycyclic Aromatic Hydrocarbons
- 1 October 1996
- journal article
- research article
- Published by Taylor & Francis in Polycyclic Aromatic Compounds
- Vol. 9 (1) , 1-23
- https://doi.org/10.1080/10406639608031196
Abstract
Recent investigations into the mechanisms of carcinogenesis of polycyclic aromatic hydrocarbons (PAHs) are discussed with major emphasis on the diol epoxide pathway. These investigations are in three principal areas: (1) enantiospecific synthesis of dihydrodiol and diol epoxide metabolites; (2) sitespecific synthesis of PAH-oligonucleotide adducts; and (3) studies of bis−dihydrodiol (i.e. tetrahydrotetraol) and tetraol monoepoxide metabolites.Keywords
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