Characterization of cholecystokinin octapeptide‐stimulated endogenous dopamine release from rat nucleus accumbens in vitro

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Abstract
1 The effect of cholecystokinin sulphated octapeptide (CCK8S) on endogenous dopamine release was examined in rat striatal and nucleus accumbens slices, by high performance liquid chromatography (h.p.l.c.) with electrochemical detection. 2 CCK8S was shown to increase dopamine release from slices of nucleus accumbens but not striatum in a dose-dependent manner between 0.1 and 10 μm. 3 Pentagastrin was without effect on dopamine release at doses up to 10 μm. 4 The dopamine release produced in the presence of CCK8S was abolished by preincubation of the slice with 1.0 or 10.0 nm L-364,718 (the CCKA-selective antagonist) while 1 μm L-365,260 (the CCKB-selective antagonist) had no action. 5 These results suggest that the CCK8S-evoked release of dopamine from the nucleus accumbens is mediated by a CCKA-receptor.