Salicylate kinetics in old age

Publisher Website
Google Scholar
Abstract
Salicylate kinetics were determined in 28 subjects 25-92 yr old who received single, oral doses of sodium salicylate (1 g/1.73 m2). The serum AUC.infin. [area under concentration] of total salicylate did not correlate with age. There was a weak positive correlation between the AUC.infin. of free (unbound) drug and age, but there was no apparent difference between the AUC.infin. values of the 15 women and 13 men. Seven of the 16 subjects > 70 yr of age cleared salicylate at about the same rate as the younger subjects. A comparison of these 7 subjects with the 9 > 70 yr old who were slow eliminators of salicylate revealed that the latter group consisted of more bedridden patients and that these patients had somewhat lower serum albumin concentrations, but they did not differ from the more rapid eliminators with respect to serum creatinine or urea nitrogen levels, SGOT [serum glutamic oxaloacetic transaminase], average age, female/male ratio, and average body weight. The serum protein binding of salicylate decreased with increasing age, apparently due mainly to decreasing serum albumin concentrations.