Helicobacter pylori and Zollinger-Ellison syndrome

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Abstract
Helicobacter pylori (previouslyCampylobacter pylori) is almost invariably associated with chronic duodenal ulcer disease. The relationship betweenH. pylori infection and duodenal ulcer in Zollinger-Ellison syndrome is unknown. We investigated the frequency ofH. pylori infection in Zollinger-Ellison syndrome and also what effectH. pylori infection had on gastric function in patients with Zollinger-Ellison syndrome.H. pylori infection was diagnosed based on a specific serologic (ELISA) assay based on high-molecular-weight cell-associated proteins ofH. pylori. We studied 20 patients with Zollinger-Ellison syndrome; 15 men and 5 women ranging in age from 24 to 71 years, median age 51. Six Zollinger-Ellison syndrome patients hadH. pylori infection compared to 100 consecutive patients with chronic recurrent duodenal ulcer disease (PH. pylori-infected patients than the uninfected patients (BAO 24.5±6.5 vs 45.4±6.6, and MAO 44.3±11.8 vs 67.9±10.7, forH. pylori infected vs uninfected patients, respectively). The difference in BAO was statistically significant (PH. pylori is not a major contributing factor in duodenal ulcer associated with Zollinger-Ellison syndrome. The association of a reduced BAO withH. pylori suggests that these findings may be related.