Diabetes Insipidus in Pregnancy Associated with Abnormally High Circulating Vasopressinase Activity

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Abstract
SEVERAL authors have described syndromes of diabetes insipidus that begin during gestation and remit after delivery.1 Barron et al.2 recently described three pregnant women with diabetes insipidus resistant to arginine vasopressin (AVP). Since excessive plasma levels of vasopressinase activity were not excluded as a cause of the disorder, the authors labeled the disease as vasopressin-resistant, but not nephrogenic, diabetes insipidus. They suggested, as had others,3 that some instances of pregnancy-associated diabetes insipidus may be due to an enhanced activity of vasopressinase. This report describes the occurrence in a woman in the third trimester of pregnancy of diabetes insipidus characterized by . . .