Clinical and Roentgenological Study of the Effects of Hormonal Therapy on Bone Growth

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Abstract
The effect of hormonal therapy on growth in children has been under investigation in the Endocrine Clinic of the Beth Israel Hospital for the past eight years. Growth rate observations were made not only on children treated for growth deficiency, but also on those showing hypogenitalism, cryptorchidism, pseudo-Fröhlich's syndrome, obesity, and mental retardation. Clinical observations of growth and of genital and somatic development were conducted. Prior to, during, and after therapy, routine roentgen studies of the skull, sella turcica, and long bones were made at regular intervals. The skeletal age was estimated by the epiphyseal development of the distal ends of the radius, ulna, metacarpals, and the phalanges of the hands, by the presence of the centers of ossification, and the number of carpal bones. The progress of skeletal development was judged in accordance with the standards of Todd (18). The degree of mineralization was estimated by those standards established for the study of osseous structure...

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