ENCEPHALITIS IN EXPERIMENTAL COXSACKIE B-3 INFECTION

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Abstract
A study has been made of the vulnerability of various parts of the brain in experimental Coxsackie B-3 virus infection. The standard prototype Coxsackie B-3 virus and a stock of inbred albino mice have been used for this purpose. The sites of greatest susceptibility have been precisely defined by thorough examinations of the whole brain and it has been observed that in 7- to 12-day-old mice the lesions are confined to sensory centers.Furthermore, observations have been made upon the effects of various factors such as the age at the time of inoculation, the state of myelination in different parts of the brain, and the route of inoculation. The complete resistance of the cerebellum to damage in spite of multiplication of virus in this site is of considerable interest.In the past little attention has been paid to the anatomical distribution of the brain lesions caused by the Coxsackie group B virus. It would seem to be profitable to direct attention to the features of the experimental disease in view of our lack of basic information regarding many non-fatal illnesses which affect the brain.