Comparative studies on immune responses to infection in susceptible B10.BR mice infected with different strains of the murine nematode parasite Trichuris muris

Publisher Website
Google Scholar
Abstract
A comparison of immune responses to infection between groups of B10.BR mice infected with different strains of T. muris, S strain (isolated in Sobreda, Portugal), E strain (isolated in Edinburgh), and E‐J strain (originally E strain, which has been maintained in our laboratory, Japan), was performed. In mice infected with E and E‐J strains, most of the worms were expelled by day 32 after infection, though the expulsion was faster in E‐J strain‐infected mice. In contrast, no expulsion was observed in S strain‐infected mice by day 32 and egg production occurred on day 32. IL‐4 production occurred in concanavalin A (Con‐A)‐stimulated mesenteric lymph node cells (MLNC) from B10.BR mice infected with E and E‐J strains, whereas no IL‐4 production was observed in S strain‐infected mice. IL‐4 production did not occur in normal mice. In comparison with normal mice, high levels of IFN‐γ production by Con A‐stimulated MLNC were detected in mice infected with every strain of T. muris. IFN‐γ production in S strain‐infected mice was greater, occurred earlier and was more persistent than in mice infected with E and E‐J strains. IgG1 and IgG2a antibodies to T. muris excretory/secretory antigens were observed in B10.BR mice infected with every strain of T. muris. Antibody production showed similar kinetics. These differences in the expulsion kinetics and IL‐4 production in B10.BR mice infected with S, E, and E‐J strains suggest the involvement of IL‐4 in protection against T. muris infection, and confirm the previous conclusion by Else et al. (1994).

This publication has 0 references indexed in Scilit: