Induction of Phenotypic Lymphocyte Differentiation in LPS Unresponsive Mice by an LPS-Induced Serum Factor and by Lipid A-Associated Protein
Open Access
- 1 May 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 118 (5) , 1910-1911
- https://doi.org/10.4049/jimmunol.118.5.1910
Abstract
Summary: Spleen cells from C3H/HeJ mice are known to be unresponsive to mitogenic stimulation by LPS. We show here that T and B cell precursors of C3H/HeJ mice are unresponsive to induction of differentiation by LPS. Phenotypic differentiation of C3H/HeJ lymphocytes can be induced with DB-cAMP, Lipid A-associated protein, and with a serum factor induced by LPS in LPS responder strains.This publication has 3 references indexed in Scilit:
- Isolation of a lipid a bound polypeptide responsible for LPS- initiated mitogenesis of C3H/HeJ spleen cellsThe Journal of Experimental Medicine, 1976
- Endotoxin protein: a B-cell mitogen and polyclonal activator of C3H/HeJ lymphocytes.The Journal of Experimental Medicine, 1976
- Ontogeny of murine B lymphocytes: sequence of B-cell differentiation from surface-immunoglobulin-negative precursors to plasma cells.Proceedings of the National Academy of Sciences, 1976