Hepatic drug disposition in multiple organ failure

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Abstract
In 15 patients with multiple organ failure of septic etiology, some principal partial hepatic functions of drug disposition were mesured by the test substances galactose, indocyanine green, theophylline and 4-methylumbelliferon. Glucuronidation was not impaired in any case, whereas flow-limited and capacity-limited drug elimination can be influenced. During monitoring and intense clinical observation seem necessary to improve drug therapy and the outcome of patients with multiple organ failure.