Screening for human ADME/Tox drug properties in drug discovery
Top Cited Papers
- 1 April 2001
- journal article
- Published by Elsevier in Drug Discovery Today
- Vol. 6 (7) , 357-366
- https://doi.org/10.1016/s1359-6446(01)01712-3
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Effects of cytochrome P450 inducers on 17α-ethinyloestradiol (EE2 ) conjugation by primary human hepatocytesPublished by Wiley ,1999
- Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potentialChemico-Biological Interactions, 1999
- The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.Journal of Clinical Investigation, 1998
- Managing the drug discovery/development interfaceDrug Discovery Today, 1997
- Strategic proposals for predicting drug-drug interactions during new drug development: Based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.The Journal of Toxicological Sciences, 1996
- Success rates for new drugs entering clinical testing in the United StatesClinical Pharmacology & Therapeutics, 1995
- Warnings Issued on Nonsedating Antihistamines Terfenadine and AstemizolePublished by American Medical Association (AMA) ,1992
- The Human Hepatic Cytochromes P450 Involved in Drug MetabolismCritical Reviews in Toxicology, 1992
- Optimization of Cryopreservation Procedures for Rat and Human HepatocytesXenobiotica, 1989
- A fluorometric method for determination of oxidized and reduced glutathione in tissuesAnalytical Biochemistry, 1976