ENZYMATIC HYDROXYLATION OF PROLINE IN MICROSOMAL POLYPEPTIDE LEADING TO FORMATION OF COLLAGEN
- 1 February 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 53 (2) , 335-342
- https://doi.org/10.1073/pnas.53.2.335
Abstract
It has been found that the conversion of unhydroxylated microsomal-bound polypeptide to collagen requires a hydrogen donor, another nonenzymatic factor in the soluble protein fraction and microsomes. Ascorbate or 2-amino-4-hydroxydimethyl-pteridine can serve as the hydrogen donor. Proline hydroxylase appears to be located in the microsomal fraction.Keywords
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