Modulating Effect of Limbic Structures on Gonadotropin Release

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Abstract
Serum and pituitary LH and FSH were measured during the estrous cycle, following electrical stimulation of the medial preoptic area (MPO), medial part of the amygdala (AMYG), and dorsal hippocampus (HPC). MPO stimulation induced elevation of serum and pituitary LH throughout the estrous cycle, and of FSH on the day of proestrus. AMYG stimulation elevated serum LH and FSH on the day of proestrus, only. Both serum and pituitary prolactin were decreased by either MPO or AMYG stimulation throughout the cycle. HPC stimulation did not alter the basal level of serum LH or FSH, but inhibited the elevation of serum LH and FSH normally resulting from MPO stimulation. The FSH concentration of the anterior pituitary gland was increased by HPC stimulation alone or in combination with MPO stimulation, while the MPO-induced elevation of pituitary LH was inhibited by HPC stimulation. HPC stimulation alone induced a decrease of serum prolactin and no change in pituitary prolactin. However, HPC stimulation in combination with MPO stimulation facilitated the MPO-induced decrease of serum prolactin and inhibited the MPO-induced decrease of pituitary prolactin on the day of proestrus. Furthermore, electrical stimulation of AMYG or the medial septum elevated the multiple unit activity in MPO and the arcuate nucleus, when ovulation was observed on the following day. Stimulation of HPC inhibited the MPO-induced elevation of multiple unit activity in the ARC as well as the ovulation normally so induced.

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