Disturbances of the Blood-Brain Barrier in Cerebrovascular Disorders

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Abstract
The changes of the blood-brain barrier (BBB) play undoubtedly a significant role in pathophysiology of cerebrovascular disorders. First of all, breakdown of the BBB associated with extravasation of serum proteins leads to development of vasogenic brain edema in the brain tissue. Furthermore, there may occur, as it was observed in cerebral ischemia, an abnormal passage from the blood of various pharmacologically active substances, such as biogenic amines, entry of which is otherwise restricted by a normally functioning barrier. Finally, the BBB dysfunction, associated with faulty out-transport of metabolites and removal of toxic waste products, may contribute to tissue damage.