GROWTH OF HERPES-SIMPLEX AND CYTOMEGALO-VIRUS IN CULTURED HUMAN ALVEOLAR MACROPHAGES
- 1 January 1979
- journal article
- research article
- Published by Elsevier
- Vol. 119 (2) , 287-291
- https://doi.org/10.1164/arrd.1979.119.2.287
Abstract
In laboratory animals, macrophages play a central role in controlling certain viral infections. Because the adult human lung is more susceptible to infection with cytomegalovirus than herpes simplex virus, the replication of these 2 viruses in vitro in human alveolar macrophages was compared. The growth of herpes simplex virus in alveolar macrophages was extremely limited, peak titers being only 1.8-fold greater than adsorbed virus titers. Cytomegalovirus, replicated in normal adult alveolar macrophages to the same extent as in permissive tissue culture cells. The human alveolar macrophage may play a central role in the control of lung infection with herpes simplex virus.This publication has 1 reference indexed in Scilit:
- Bronchopulmonary Lavage in Normal Subjects and Patients with Obstructive Lung DiseaseAnnals of Internal Medicine, 1967