Primary cutaneous plasmacytoma: treatment with intralesional tumour necrosis factor-α

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Abstract
We report a case of primary multiple cutaneous plasmacytomas, without underlying multiple myeloma, treated with intralesional tumour necrosis factor‐α (TNE‐α). A marked reduction in tumour size, with no significant adverse effects, suggests that intralesional TNF‐α is an effective treatment for non‐solid malignant tumours. Extramedullary plasmacytoma, especially involving the skin as a primary site, has rarely been reported in the English literature. We describe the ninth reported case of multiple cutaneous plasmacytomas without underlying multiple myeloma. Intralesional tumour necrosis factor‐α (TNF‐α) was used to treat this disease and its anti‐tumour effect quantitatively evaluated by comparing the tumour size and histological change before and after treatment.