Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. III. The Antioxidative Activities of the Commercial Preparations of Sodium Copper Chlorophyllin
Open Access
- 1 January 1980
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 100 (5) , 580-584
- https://doi.org/10.1248/yakushi1947.100.5_580
Abstract
Several commercial preparations of sodium copper chlorophyllin(Cu-Chl-Na) containing Cu chelate compounds of chlorophyll derivatives were examined for their lipid peroxidation inhibitory activities in rat liver homogenates. The inhibitory effect on lipid peroxidation stimulated by both Fe2+ and ascorbic acid differed from preparation to preparation. The potency of the antioxidative activity was correlated with the intensity of the absorption maximum at .apprx. 628 nm, presumably due to the chemical structure of the Cu complexes of chlorin derivatives. The sample which did not show any absorption in the red-band region exerted no effect on lipid peroxidation. The Cu-Chl-Na preparation, which contains a larger amount of Cu complexes of chlorin derivatives, has more potent antioxidant activity. Sodium iron chlorophyllin showed inhibitory action on lipid peroxidation in rat liver homogenates; the antioxidative effect is not specific for Cu-Chl-Na.Keywords
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