Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists
- 22 September 2004
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 14 (22) , 5513-5519
- https://doi.org/10.1016/j.bmcl.2004.09.010
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- N-4-Methansulfonamidobenzyl-N′-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligandsBioorganic & Medicinal Chemistry Letters, 2004
- N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2 H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: II. In Vivo Characterization in Rat Models of Inflammatory and Neuropathic PainThe Journal of Pharmacology and Experimental Therapeutics, 2003
- N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2 H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic PropertiesThe Journal of Pharmacology and Experimental Therapeutics, 2003
- N-(3-Acyloxy-2-benzylpropyl)-N‘-[4-(methylsulfonylamino)benzyl]thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid ReceptorJournal of Medicinal Chemistry, 2003
- The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic PainThe Journal of Pharmacology and Experimental Therapeutics, 2003
- Cloning and functional expression of a human orthologue of rat vanilloid receptor-1Pain, 2000
- The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing StimuliNeuron, 1998
- Euphorbium: Modern research on its active principle, resiniferatoxin, revives an ancient medicinePublished by Elsevier ,1998
- The Discovery of Capsazepine, the First Competitive Antagonist of the Sensory Neuron Excitants Capsaicin and ResiniferatoxinJournal of Medicinal Chemistry, 1994
- A spinal mechanism of action is involved in the antinociception produced by the capsaicin analogue NE 19550 (olvanil)Pain, 1990