The effects of recombinant CSF‐1 on the blast cells of acute myeloblastic leukemia in suspension culture

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Abstract
Recombinant hemopoietic colony‐stimulating factors (CSFs), including GM‐CSF, G‐CSF and IL‐3, have been shown to be effective stimulators of both self‐renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF‐1 (or M‐CSF), on the growth of leukemic blasts in culture. CSF‐1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF‐1 often stimulated the production of adherent blast cells incapable of division. This observation leads us to suggest that CSF‐1 may be useful in the treatment of selected cases of AML.