Decreased Resistance of Pyridoxine-Deficient Rats to Gold Exposure.

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Abstract
Immature rats were fed a purified ration containing all the known B vitamins in synthetic form and a similar diet with pyridoxine omitted. Tests were conducted in which rats fed the above diets were exposed to cold (2 ± 1.5°C) from the first day of feeding or after an experimental period of 80 days. 68.8% of the pyridoxine-deficient rats in the latter group succumbed during a 20 day period of cold exposure in contrast to a 0% mortality for animals fed a similar diet supplemented with pyridoxine hydrochloride. In the group exposed to cold from the first day of feeding mortality was 25.0% and 18.7% respectively for rats fed the pyridoxine-deficient and control ration for a period of 100 days.